Dichotomous Effects of Glypican-4 on Cancer Progression and Its Crosstalk with Oncogenes.

ABSTRACT: Glypicans are linked to various aspects of neoplastic behavior, and their therapeutic value has been proposed in different cancers. Here, we have systematically assessed the impact of GPC4 on cancer progression through functional genomics and transcriptomic analyses across a broad range of cancers. Survival analysis using TCGA cancer patient data reveals divergent effects of GPC4 expression across various cancer types, revealing elevated GPC4 expression levels to be associated with both poor and favorable prognoses in a cancer-dependent manner. Detailed investigation of the role of GPC4 in glioblastoma and non-small cell lung adenocarcinoma by genetic perturbation studies displays opposing effects on these cancers, where the knockout of GPC4 with CRISPR/Cas9 attenuated

SUBMITTER: Cherouvrier Hansson V 

PROVIDER: S-EPMC11012302 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature