Complement MASP-1 Modifies Endothelial Wound Healing.

ABSTRACT: Endothelial wound-healing processes are fundamental for the maintenance and restoration of the circulatory system and are greatly affected by the factors present in the blood. We have previously shown that the complement protein mannan-binding lectin-associated serine protease-1 (MASP-1) induces the proinflammatory activation of endothelial cells and is able to cooperate with other proinflammatory activators. Our aim was to investigate the combined effect of mechanical wounding and MASP-1 on endothelial cells. Transcriptomic analysis showed that MASP-1 alters the expression of wound-healing-related and angiogenesis-related genes. Both wounding and MASP-1 induced Ca²⁺ mobilization when applied individually. However, MASP-1-induced Ca²⁺ mobilization was inhibited when t

SUBMITTER: Nemeth Z 

PROVIDER: S-EPMC11012537 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature