Zinc(II) Iminopyridine Complexes as Antibacterial Agents: A Structure-to-Activity Study.

ABSTRACT: Antibiotic resistance is currently a global health emergency. Metallodrugs, especially metal coordination complexes, comprise a broad variety of candidates to combat antibacterial infections. In this work, we designed a new family of Schiff base zinc(II) complexes with iminopyridine as an organic ligand and different inorganic ligands: chloride, nitrate, and acetate. The antibacterial effect of the Zn(II) complexes was studied against planktonic bacterial cells of Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) strains. The results showed a moderate biocide activity in both types of planktonic bacteria, which arises from the metal complexation to the Schiff base ligand. Importantly, we confirmed the crucial effect of the metal, with Zn(II) improving

SUBMITTER: de la Mata Moratilla S 

PROVIDER: S-EPMC11012978 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature