Monitoring Pharmaceuticals and Personal Care Products in Healthcare Effluent Wastewater Samples and the Effectiveness of Drug Removal in Wastewater Treatment Plants Using the UHPLC-MS/MS Method.

ABSTRACT: A multi-residue UHPLC-MS/MS analytical method, previously developed for monitoring 52 pharmaceuticals in drinking water, was used to analyse these pharmaceuticals in wastewater originating from healthcare facilities in the Czech Republic. Furthermore, the methodology was expanded to include the evaluation of the effectiveness of drug removal in Czech wastewater treatment plants (WWTPs). Of the 18 wastewater samples analysed by the validated UHPLC-MS/MS, each sample contained at least one quantifiable analyte. This study reveals the prevalence of several different drugs; mean concentrations of 702 μg L^-1 of iomeprol, 48.8 μg L^-1 of iopromide, 29.9 μg L^-1 of gabapentin, 42.0 μg L^-1 of caffeine and 82.5 μg L^-1 of paracetamol were present.

SUBMITTER: Molnarova L 

PROVIDER: S-EPMC11013191 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature