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Phenylspirodrimane with Moderate Reversal Effect of Multidrug Resistance Isolated from the Deep-Sea Fungus Stachybotrys sp. 3A00409.

ABSTRACT: Two new phenylspirodrimanes, stachybotrins K and L (1 and 2), together with eight known analogues (3-10), were isolated from deep-sea-derived Stachybotrys sp. MCCC 3A00409. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Absolute configurations of new compounds were determined through a comparison of their circular dichroism (CD) spectra with other reported compounds. The possible reversal effects of all compounds were assayed in the resistant cancer cell lines. Stachybotrysin B (8) can reverse multidrug resistance (MDR) in ABCB1-overexpression cells (KBv200, Hela/VCR) at the non-cytotoxic concentration. Doxorubicin accumulation assay and molecular-docking analysis reveal that the mechanism of its reversal MDR effect may be related to the increase in the intracellular concentration of substrate anticancer drugs.

SUBMITTER: Ma X 

PROVIDER: S-EPMC11013241 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Phenylspirodrimane with Moderate Reversal Effect of Multidrug Resistance Isolated from the Deep-Sea Fungus <i>Stachybotrys</i> sp. 3A00409.

Ma Xinhua X   Wu Min M   Chen Zhenwei Z   Cao Fan F   Zhong Tianhua T   Luo Zhuhua Z   Shao Zongze Z   Zhang Yonghong Y   Chen Limin L   Zhang Zhiqiang Z  

Molecules (Basel, Switzerland) 20240408 7

Two new phenylspirodrimanes, stachybotrins K and L (<b>1</b> and <b>2</b>), together with eight known analogues (<b>3</b>-<b>10</b>), were isolated from deep-sea-derived <i>Stachybotrys</i> sp. MCCC 3A00409. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Absolute configurations of new compounds were determined through a comparison of their circular dichroism (CD) spectra with other reported compounds. The possible reversal effects of all compounds were as  ...[more]

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