Effects of a High-Fat Diet on Insulin-Related miRNAs in Plasma and Brain Tissue in APP_Swe/PS1dE9 and Wild-Type C57BL/6J Mice.

ABSTRACT: Insulin resistance (IR)-related miRNAs have been associated with the development and progression of Alzheimer's disease (AD). The dietary modulation of these miRNAs could become a potential strategy to manage AD. The aim of this study was to evaluate the effect of a high-fat diet (HFD), which aggravates AD-related pathogenic processes, on serum, cortex and hippocampus IR-related miRNA expression. C57BL/6J WT and APP_Swe/PS1dE9 mice were fed either an HFD or a conventional diet till 6 months of age. The mice fed with the HFD showed a significant increase in body weight and worsening glucose and insulin metabolism. miR-19a-3p was found to be up-regulated in the cortex, hippocampus and serum of APP/PS1 mice and in the serum and hippocampus of WT mice fed with the HFD. miR-34a-5p and

SUBMITTER: Rojas-Criollo M 

PROVIDER: S-EPMC11013640 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature