Novel mechanisms of diversity generation in Acinetobacter baumannii resistance islands driven by Tn7-like elements.

ABSTRACT: Mobile genetic elements play an important role in the acquisition of antibiotic and biocide resistance, especially through the formation of resistance islands in bacterial chromosomes. We analyzed the contribution of Tn7-like transposons to island formation and diversification in the nosocomial pathogen Acinetobacter baumannii and identified four separate families that recognize different integration sites. One integration site is within the comM gene and coincides with the previously described Tn6022 elements suggested to account for the AbaR resistance island. We established Tn6022 in a heterologous E. coli host and confirmed basic features of transposition into the comM attachment site and the use of a novel transposition protein. By analyzing population features within Tn6022 elements

SUBMITTER: Correa A 

PROVIDER: S-EPMC11014353 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature