Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination.

ABSTRACT: Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are related to essential targets of the posttranslational modification neddylation, although how these lead to myelin defects is unclear. Here, we demonstrate that inhibiting neddylation leads to a notable absence of peripheral myelin and axonal loss both in developing and regenerating mouse nerves. Our data indicate that neddylation exerts a global influence on the complex transcriptional and posttranscriptional program by simultaneously regulating the expression and function of multiple essential myelination signals, including the master transcrip

SUBMITTER: Ayuso-Garcia P 

PROVIDER: S-EPMC11014456 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature