The oocyte microenvironment is altered in adolescents compared to oocyte donors.

ABSTRACT:

Study question

Are the molecular signatures of cumulus cells (CCs) and follicular fluid (FF) of adolescents undergoing fertility preservation differ from that of reproductively adult oocyte donors?

Summary answer

The microenvironment immediately surrounding the oocyte, including the CCs and FF, is altered in adolescents undergoing fertility preservation compared to oocyte donors.

What is known already

Adolescents experience a period of subfecundity following menarche. Recent evidence suggests that this may be at least partially due to increased oocyte aneuploidy. Reproductive juvenescence in mammals is associated with suboptimal oocyte quality.

Study design size duration

This was a prospective cohort study. Adolescents (10-19 years old, N=23) and oocyte donors

SUBMITTER: Gokyer D 

PROVIDER: S-EPMC11014529 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature