Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states.

ABSTRACT: While accumulated publications support the existence of neurogenesis in the adult human hippocampus, the homeostasis and developmental potentials of neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas of the human hippocampus across neonatal, adult, aging, and injury, we dissected the molecular heterogeneity and transcriptional dynamics of human hippocampal NSCs under different contexts. We further identified new specific neurogenic lineage markers that overcome the lack of specificity found in some well-known markers. Based on developmental trajectory and molecular signatures, we found that a subset of NSCs exhibit quiescent properties after birth, and most NSCs become deep quiescence during aging. Furthermore, certain deep quiesce

SUBMITTER: Yao J 

PROVIDER: S-EPMC11014727 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature