Impact of Methylthioxylose Substituents on the Biological Activities of Lipomannan and Lipoarabinomannan in <i>Mycobacterium tuberculosis</i>.

ABSTRACT: Two lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM), play various, albeit incompletely defined, roles in the interactions of mycobacteria with the host. Growing evidence points to the modification of LM and LAM with discrete covalent substituents as a strategy used by these bacteria to modulate their biological activities. One such substituent, originally identified in Mycobacterium tuberculosis (Mtb), is a 5-methylthio-d-xylose (MTX) sugar, which accounts for the antioxidative properties of LAM. The widespread distribution of this motif across Mtb isolates from several epidemiologically important lineages have stimulated interest in MTX-modified LAM as a biomarker of tuberculosis infection. Yet, several lines of evidence indicate that MTX may not be restricte

SUBMITTER: Palcekova Z 

PROVIDER: S-EPMC11014759 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature