Modeling cerebrovascular responses to assess the impact of the collateral circulation following middle cerebral artery occlusion.

ABSTRACT:

Objective

An improved understanding of the role of the leptomeningeal collateral circulation in blood flow compensation following middle cerebral artery (MCA) occlusion can contribute to more effective treatment development for ischemic stroke. The present study introduces a model of the cerebral circulation to predict cerebral blood flow and tissue oxygenation following MCA occlusion.

Methods

The model incorporates flow regulation mechanisms based on changes in pressure, shear stress, and metabolic demand. Oxygen saturation in cerebral vessels and tissue is calculated using a Krogh cylinder model. The model is used to assess the effects of changes in oxygen demand and arterial pressure on cerebral blood flow and oxygenation after MCA occlusion.

Results

An increase fr

SUBMITTER: Zhao E 

PROVIDER: S-EPMC11014771 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature