ABCC4 suppresses glioblastoma progression and recurrence by restraining cGMP-PKG signalling.

ABSTRACT:

Background

Cyclic nucleotides are critical mediators of cellular signalling in glioblastoma. However, the clinical relevance and mechanisms of regulating cyclic nucleotides in glioblastoma progression and recurrence have yet to be thoroughly explored.

Methods

In silico, mRNA, and protein level analyses identified the primary regulator of cyclic nucleotides in recurrent human glioblastoma. Lentiviral and pharmacological manipulations examined the functional impact of cyclic nucleotide signalling in human glioma cell lines and primary glioblastoma cells. An orthotopic xenograft mice model coupled with aspirin hydrogels verified the in vivo outcome of targeting cyclic nucleotide signalling.

Results

Elevated intracellular levels of cGMP, instead of cAMP, due to a lower su

SUBMITTER: Chiang JY 

PROVIDER: S-EPMC11014854 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature