Appropriate glycemic management protects the germline but not the uterine environment in hyperglycemia.

ABSTRACT: Emerging evidence indicates that parental diseases can impact the health of subsequent generations through epigenetic inheritance. Recently, it was shown that maternal diabetes alters the metaphase II oocyte transcriptome, causing metabolic dysfunction in offspring. However, type 1 diabetes (T1D) mouse models frequently utilized in previous studies may be subject to several confounding factors due to severe hyperglycemia. This limits clinical translatability given improvements in glycemic control for T1D subjects. Here, we optimize a T1D mouse model to investigate the effects of appropriately managed maternal glycemic levels on oocytes and intrauterine development. We show that diabetic mice with appropriate glycemic control exhibit better long-term health, including maintenance of the ooc

SUBMITTER: Zhao A 

PROVIDER: S-EPMC11014859 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature