HER2 expression and genOmic characterization of rESected brain metastases from colorectal cancer: the HEROES study.

ABSTRACT:

Background

Little is known about prognostic factors of brain metastases (BM) from colorectal cancer (CRC). HER2 amplification/overexpression (HER2+) was previously described; its impact on prognosis remains uncertain.

Methods

In the translational study HEROES, extensive molecular analysis was performed on primary CRC (prCRC) and their matched resected BM by means of NGS comprehensive genomic profiling and HER2 status as assessed by immunohistochemical/ in situ hybridization. Count of tumour-infiltrating lymphocytes (TILs) was also performed.

Primary objective

to describe the molecular landscape of paired BM/prCRC.

Secondary objectives

to search for new prognostic biomarkers of outcome after BM resection: intracranial-only Progression-Free Survival (BM-iPFS), Pr

SUBMITTER: Prete AA 

PROVIDER: S-EPMC11014920 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature