Annelid adult cell type diversity and their pluripotent cellular origins.

ABSTRACT: Many annelids can regenerate missing body parts or reproduce asexually, generating all cell types in adult stages. However, the putative adult stem cell populations involved in these processes, and the diversity of cell types generated by them, are still unknown. To address this, we recover 75,218 single cell transcriptomes of the highly regenerative and asexually-reproducing annelid Pristina leidyi. Our results uncover a rich cell type diversity including annelid specific types as well as novel types. Moreover, we characterise transcription factors and gene networks that are expressed specifically in these populations. Finally, we uncover a broadly abundant cluster of putative stem cells with a pluripotent signature. This population expresses well-known stem cell markers such as vasa, piw

SUBMITTER: Alvarez-Campos P 

PROVIDER: S-EPMC11014941 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature