TCTP regulates genotoxic stress and tumorigenicity via intercellular vesicular signaling.

ABSTRACT: Oncogenic intercellular signaling is regulated by extracellular vesicles (EVs), but the underlying mechanisms remain mostly unclear. Since TCTP (translationally controlled tumor protein) is an EV component, we investigated whether it has a role in genotoxic stress signaling and malignant transformation. By generating a Tctp-inducible knockout mouse model (Tctp^-/f-), we report that Tctp is required for genotoxic stress-induced apoptosis signaling via small EVs (sEVs). Human breast cancer cells knocked-down for TCTP show impaired spontaneous EV secretion, thereby reducing sEV-dependent malignant growth. Since Trp53^-/- mice are prone to tumor formation, we derived tumor cells from Trp53^-/-;Tctp^-/f- double mutant mice and describe a drastic decrease

SUBMITTER: Amson R 

PROVIDER: S-EPMC11014985 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature