In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design.

ABSTRACT: Organ-on-a-chip (OoC) systems are a promising new class of in vitro devices that can combine various tissues, cultured in different compartments, linked by media flow. The properties of these novel in vitro systems linked to increased physiological relevance of culture conditions may lead to more in vivo-relevant cell phenotypes, enabling better in vitro pharmacology and toxicology assessment. Improved cell activities combined with longer lasting cultures offer opportunities to improve the characterization of absorption, distribution, metabolism, and excretion (ADME) processes, potentially leading to more accurate prediction of human pharmacokinetics (PKs). The inclusion of barrier tissue elements and metabolically competent tissue types results in complex concentration-time profiles (in v

SUBMITTER: Milani N 

PROVIDER: S-EPMC11015085 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature