Association of maternal weight gain in early pregnancy with congenital heart disease in offspring: a China birth cohort study.

ABSTRACT:

Objectives

Little study has reported the association of maternal weight gain in early pregnancy with fetal congenital heart disease (CHD). We aimed to explore the potential relationship based on a China birth cohort while adjusting by multiple factors.

Design

Cohort study.

Setting

China birth cohort study conducted from 2017 to 2021.

Participants

The study finally included 114 672 singleton pregnancies in the 6-14 weeks of gestation, without missing data or outliers, loss to follow-up or abnormal conditions other than CHD. The proportion of CHD was 0.65% (749 cases).

Primary and secondary outcome measures

Association between maternal pre-pregnancy weight gain and CHD in the offspring were analysed by multivariate logistic regression, with the unadjusted,

SUBMITTER: Wang J 

PROVIDER: S-EPMC11015207 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature