Exacerbating effects of circadian rhythm disruption on the systemic lupus erythematosus.

ABSTRACT:

Objective

Circadian rhythm disruption (CRD) has been associated with inflammation and immune disorders, but its role in SLE progression is unclear. We aimed to investigate the impact of circadian rhythms on immune function and inflammation and their contribution to SLE progression to lupus nephritis (LN).

Methods

This study retrospectively analysed the clinical characteristics and transcriptional profiles of 373 samples using bioinformatics and machine-learning methods. A flare risk score (FRS) was established to predict overall disease progression for patients with lupus. Mendelian randomisation was used to analyse the causal relationship between CRD and SLE progression.

Results

Abnormalities in the circadian pathway were detected in patients with SLE, and lower enri

SUBMITTER: Shen L 

PROVIDER: S-EPMC11015241 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature