Influence of vitamin D supplementation on growth, body composition, pubertal development and spirometry in South African schoolchildren: a randomised controlled trial (ViDiKids).

ABSTRACT:

Objective

To determine whether weekly oral vitamin D supplementation influences growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren.

Design

Phase 3 double-blind randomised placebo-controlled trial.

Setting

Socioeconomically disadvantaged peri-urban district of Cape Town, South Africa.

Participants

1682 children of black African ancestry attending government primary schools and aged 6-11 years at baseline.

Interventions

Oral vitamin D₃ (10 000 IU/week) versus placebo for 3 years.

Main outcome measures

Height-for-age and body mass index-for-age, measured in all participants; Tanner scores for pubertal development, spirometric lung volumes and body composition, measured in a subset of 450

SUBMITTER: Middelkoop K 

PROVIDER: S-EPMC11015302 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature