¹H-NMR-based urine metabolomics of prostate cancer and benign prostatic hyperplasia.

ABSTRACT:

Background

Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are prevalent conditions affecting a significant portion of the male population, particularly with advancing age. Traditional diagnostic methods, such as digital rectal examination (DRE) and prostate-specific antigen (PSA) tests, have limitations in specificity and sensitivity, leading to potential overdiagnosis and unnecessary biopsies.

Significance

This study explores the effectiveness of ¹H NMR urine metabolomics in distinguishing PCa from BPH and in differentiating various PCa grades, presenting a non-invasive diagnostic alternative with the potential to enhance early detection and patient-specific treatment strategies.

Results

The study demonstrated the capability of ¹H

SUBMITTER: Zniber M 

PROVIDER: S-EPMC11015411 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature