Neural correlates of drinking reduction during a clinical trial of cognitive behavioral therapy for alcohol use disorder.

ABSTRACT:

Background

Cognitive behavioral therapy (CBT) is an effective treatment for alcohol use disorder (AUD). We hypothesized that the dorsolateral prefrontal cortex (DLPFC), a region implicated in cognitive control and goal-directed behavior, plays a role in behavior change during CBT by facilitating the regulation of craving (ROC).

Methods

Treatment-seeking participants with AUD (N = 22) underwent functional magnetic resonance imaging (fMRI) scanning both before and after a 12-week, single-arm trial of CBT, using an ROC task that was previously shown to engage the DLPFC.

Results

We found that both the percentage of heavy drinking days (PHDD) and the overall self-reported alcohol craving measured during the ROC task were significantly reduced from pre- to post-CBT. However

SUBMITTER: Naqvi NH 

PROVIDER: S-EPMC11015435 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature