Nigrostriatal degeneration determines dynamics of glial inflammatory and phagocytic activity.

ABSTRACT: Glial cells are key players in the initiation of innate immunity in neurodegeneration. Upon damage, they switch their basal activation state and acquire new functions in a context and time-dependent manner. Since modulation of neuroinflammation is becoming an interesting approach for the treatment of neurodegenerative diseases, it is crucial to understand the specific contribution of these cells to the inflammatory reaction and to select experimental models that recapitulate what occurs in the human disease. Previously, we have characterized a region-specific activation pattern of CD11b⁺ cells and astrocytes in the α-synuclein overexpression mouse model of Parkinson´s disease (PD). In this study we hypothesized that the time and the intensity of dopaminergic neuronal death would

SUBMITTER: Ayerra L 

PROVIDER: S-EPMC11015575 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature