Serum PM20D1 levels in patients with idiopathic pulmonary arterial hypertension and its clinical significance.

ABSTRACT:

Objective

This study aimed to investigate the serum levels of Peptidase M20 domain containing 1 (PM20D1) in idiopathic pulmonary arterial hypertension (IPAH) patients and examine its association with lipid metabolism, echocardiography, and hemodynamic parameters.

Methods

This prospective observational research enrolled 103 IPAH patients from January 2018 to January 2022. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum PM20D1 levels in all patients before treatment within 24 h of admission. Demographic data, echocardiography, hemodynamic parameters and serum biomarkers were also collected.

Results

The IPAH patients in the deceased group had significantly elevated age, right atrial (RA), mean pulmonary arterial pressure (mPAP), mean right atrial

SUBMITTER: Wang L 

PROVIDER: S-EPMC11015596 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature