Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis.

ABSTRACT:

Objective

Soluble CD27 is a promising cerebrospinal fluid inflammatory biomarker in multiple sclerosis. In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis.

Methods

Protein levels of soluble CD27 were correlated to inflammatory cell subpopulations and inflammatory cytokines and chemokines detected in cerebrospinal fluid of 137 patients with multiple sclerosis and 47 patients with inflammatory and non-inflammatory neurological disease from three independent cohorts. Production of soluble CD27 was investigated in cell cultures of activated T and B cells and CD27-knockout T cells. In a study including matched cerebrospinal fluid and post-mortem brain tissues of patients with multiple sclerosis and control cases, le

SUBMITTER: Cencioni MT 

PROVIDER: S-EPMC11015621 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature