Effect modification of polypharmacy on incident frailty by chronic kidney disease in older adults.

ABSTRACT:

Background

Frailty and polypharmacy are common conditions in older adults, especially in those with chronic kidney disease (CKD). Therefore, we analyzed the association of polypharmacy and incident frailty and the effect modification by CKD in very old adults.

Methods

In non-frail individuals within the Berlin Initiative (cohort) Study, polypharmacy (≥ 5 medications) was assessed according to multiple definitions based on the number of regular and on demand prescription and over the counter drugs, as well as vitamins and supplements. CKD was defined as an estimated glomerular filtration rate < 60 mL/min/1.73m² and/or an albumin-creatinine ratio ≥ 30 mg/g. Incident frailty was assessed at follow-up using Fried criteria. Logistic regression was applied to assess (1)

SUBMITTER: Mielke N 

PROVIDER: S-EPMC11015642 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature