Comparative study of nasal cavity drug delivery efficiency with different nozzles in a 3D printed model.

ABSTRACT:

Background

Nasal sprays are widely used in treating nasal and sinus diseases; however, there are very few studies on the drug delivery efficiency of nasal sprays. In this study, the drug delivery efficiency of three different nasal spray devices was evaluated in vitro using a 3D printed cast model of nasal cavity.

Methods

Three nasal spray devices with different nozzles and angles of administration were used in the 3D model of the nasal cavity and paranasal sinuses. The spraying area (SA), maximal spraying distance (MSD), and spraying distribution scores on the nasal septum and lateral nasal wall were recorded.

Results

Different nasal spray devices have their own characteristics, including volume of each spray, SA, and plume angle. The SA of the three nozzles o

SUBMITTER: Fang S 

PROVIDER: S-EPMC11015827 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature