Properties of [¹⁸F]FAPI monitoring of acute radiation pneumonia versus [¹⁸F]FDG in mouse models.

ABSTRACT:

Objective

In this study, the uptake characteristics of [¹⁸F]fibroblast activation protein inhibitor (FAPI) molecular imaging probe were investigated in acute radiation pneumonia and lung cancer xenografted mice before and after radiation to assess the future applicability of [¹⁸F]FAPI positron emission tomography/computed tomography (PET/CT) imaging in early radiotherapy response.

Methods

Initially, the biodistribution of [¹⁸F]FAPI tracer in vivo were studied in healthy mice at each time-point. A comparison of [¹⁸F]FAPI and [¹⁸F]fluorodeoxyglucose (FDG) PET/CT imaging efficacy in normal ICR, LLC tumor-bearing mice was evaluated. A radiation pneumonia model was then investigated using a gamma counter, small animal PET/CT,

SUBMITTER: Liu M 

PROVIDER: S-EPMC11016509 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature