Immune-related LncRNAs scores predicts chemotherapeutic responses and prognosis in cervical cancer patients.

ABSTRACT:

Background

Long non-coding RNAs (LncRNAs) regulating the immune microenvironment of cancer is a hot spot. But little is known about the influence of the immune-related lncRNA (IRlncRs) on the chemotherapeutic responses and prognosis of cervical cancer (CC) patients. The purpose of the study was to identify an immune-related lncRNAs (IRlncRs)-based model for the prospective prediction of clinical outcomes in CC patients.

Methods

CC patients' relevant data was acquired from The Cancer Genome Atlas (TCGA). Correlation analysis and Cox regression analyses were applied. A risk score formula was formulated. Prognostic factors were combined into a nomogram, while sensitivity for chemotherapy drugs was analyzed using the OncoPredict algorithm.

Results

Eight optimal IRlncRs(AT

SUBMITTER: Tian W 

PROVIDER: S-EPMC11016529 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature