Long-term Outcomes of Protocol-Based Treatment for Newly Diagnosed Medulloblastoma.

ABSTRACT:

Purpose

The Korean Society of Pediatric Neuro-Oncology (KSPNO) conducted treatment strategies for children with medulloblastoma (MB) by using alkylating agents for maintenance chemotherapy or tandem high-dose chemotherapy (HDC) with autologous stem cell rescue (ASCR) according to the risk stratification. The purpose of the study was to assess treatment outcomes and complications based on risk-adapted treatment and HDC.

Materials and methods

Fifty-nine patients diagnosed with MB were enrolled in this study. Patients in the standard-risk (SR) group received radiotherapy (RT) after surgery and chemotherapy using the KSPNO M051 regimen. Patients in the high-risk (HR) group received two and four chemotherapy cycles according to the KSPNO S081 protocol before and after reduced RT

SUBMITTER: Ahn WK 

PROVIDER: S-EPMC11016662 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature