Prediction of diabetes mellitus after kidney transplantation using patient-specific induced pluripotent stem cells.

ABSTRACT:

Background

Multiple risk factors are involved in new-onset diabetes mellitus (DM) after organ transplantation; however, their ability to predict clinical prognosis remains unclear. Therefore, we investigated whether patient-specific induced pluripotent stem cells (iPSCs) could help predict DM development before performing kidney transplantation (KT).

Methods

We first performed whole transcriptome and functional enrichment analyses of KT patient-derived iPSCs. Our results revealed that insulin resistance, type 2 DM, and transforming growth factor beta signaling pathways are associated between the groups of DM and non-DM. We next determined whether the genetic background was associated with development of iPSCs into pancreatic progenitor (PP) cells.

Results

The levels o

SUBMITTER: Lim SW 

PROVIDER: S-EPMC11016675 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature