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Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development.

ABSTRACT: Osteoporosis has gradually become a major public health problem. Further elucidation of the pathophysiological mechanisms that induce osteoporosis and identification of more effective therapeutic targets will have important clinical significance. Experiments in vitro on bone marrow stem cells (BMSCs) subjected to osteogenic and adipogenic differentiation and in vivo on surgical bilateral ovariectomy (OVX) mouse models revealed that exosomes of vascular endothelial cells (EC-EXOs) can promote osteogenic differentiation of BMSCs and inhibit BMSC adipogenic differentiation through miR-3p-975_4191. Both miR-3p-975_4191 and curcumin can target tumor necrosis factor (TNF) and act synergistically to regulate BMSCs fate differentiation and delay the progression of osteoporosis. Our findings suggest that EC-EXOs may exert a synergistic effect with curcumin in reversing the progression of osteoporosis by targeting TNF via miR-3p-975_4191. Our study may provide therapeutic options and potential therapeutic targets for osteoporosis and thus has important clinical implications.

SUBMITTER: Wang J

PROVIDER: S-EPMC11016789 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development.

Wang Jiaojiao J Xie Xinyan X Li Hang H Zheng Qiyue Q Chen Yun Y Chen Wenjie W Chen Yajun Y He Jieyu J Lu Qiong Q

iScience 20240327 4

Osteoporosis has gradually become a major public health problem. Further elucidation of the pathophysiological mechanisms that induce osteoporosis and identification of more effective therapeutic targets will have important clinical significance. Experiments <i>in vitro</i> on bone marrow stem cells (BMSCs) subjected to osteogenic and adipogenic differentiation and <i>in vivo</i> on surgical bilateral ovariectomy (OVX) mouse models revealed that exosomes of vascular endothelial cells (EC-EXOs) c ...[more]

PMID: 38623340

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Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development.

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Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development.

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