Relationship of plasma biomarkers to digital cognitive tests in Alzheimer's disease.

ABSTRACT:

Introduction

A major limitation in Alzheimer's disease (AD) research is the lack of the ability to measure cognitive performance at scale-robustly, remotely, and frequently. Currently, there are no established online digital platforms validated against plasma biomarkers of AD.

Methods

We used a novel web-based platform that assessed different cognitive functions in AD patients (N = 46) and elderly controls (N = 53) who were also evaluated for plasma biomarkers (amyloid beta 42/40 ratio, phosphorylated tau ([p-tau]181, glial fibrillary acidic protein, neurofilament light chain). Their cognitive performance was compared to a second, larger group of elderly controls (N = 352).

Results

Patients with AD were significantly impaired across all digital co

SUBMITTER: Toniolo S 

PROVIDER: S-EPMC11016819 | biostudies-literature | 2024 Apr-Jun

REPOSITORIES: biostudies-literature