Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis.

ABSTRACT:

Objectives

We aimed to cluster patients with rheumatoid arthritis (RA) based on comorbidities and then examine the association between these clusters and RA disease activity and mortality.

Methods

In this population-based study, residents of an eight-county region with prevalent RA on 1 January 2015 were identified. Patients were followed for vital status until death, last contact or 31 December 2021. Diagnostic codes for 5 years before the prevalence date were used to define 55 comorbidities. Latent class analysis was used to cluster patients based on comorbidity patterns. Standardised mortality ratios were used to assess mortality.

Results

A total of 1643 patients with prevalent RA (72% female; 94% white; median age 64 years, median RA duration 7 years) were studied

SUBMITTER: Crowson CS 

PROVIDER: S-EPMC11017091 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature