Association between lipid-lowering drugs and allergic diseases: A Mendelian randomization study.

ABSTRACT:

Background

Several observational studies suggest a possible link between lipid-lowering drugs and allergic diseases. However, inferring causality from these studies can be challenging due to issues such as bias, reverse causation, and residual confounding. To investigate the potential causal effect of lipid-lowering drugs, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) inhibitors, on allergic diseases (allergic asthma, allergic conjunctivitis, atopic dermatitis, allergic rhinitis, and allergic urticaria), we performed a Mendelian randomization (MR)-based study.

Methods

We employed MR and summary-data-based MR (SMR), analyzing genome-wide association study (GWAS) data from people of European descen

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11017355 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature