Multiparametric hippocampal signatures for early diagnosis of Alzheimer's disease using ¹⁸F-FDG PET/MRI Radiomics.

ABSTRACT:

Purpose

This study aimed to explore the utility of hippocampal radiomics using multiparametric simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) for early diagnosis of Alzheimer's disease (AD).

Methods

A total of 53 healthy control (HC) participants, 55 patients with amnestic mild cognitive impairment (aMCI), and 51 patients with AD were included in this study. All participants accepted simultaneous PET/MRI scans, including ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET, 3D arterial spin labeling (ASL), and high-resolution T1-weighted imaging (3D T1WI). Radiomics features were extracted from the hippocampus region on those three modal images. Logistic regression models were trained to classify AD and HC, AD and aMCI, aMCI and HC res

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11017421 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature