Dataset Information

Eomesodermin expression in CD4⁺T-cells associated with disease progression in amyotrophic lateral sclerosis.

ABSTRACT:

Aim

To clarify the role of Eomesodermin (EOMES) to serve as a disease-relevant biomarker and the intracellular molecules underlying the immunophenotype shifting of CD4⁺T subsets in amyotrophic lateral sclerosis (ALS).

Methods

The derivation and validation cohorts included a total of 148 ALS patients and 101 healthy controls (HCs). Clinical data and peripheral blood were collected. T-cell subsets and the EOMES expression were quantified using multicolor flow cytometry. Serum neurofilament light chain (NFL) was measured. In 1-year longitudinal follow-ups, the ALSFRS-R scores and primary endpoint events were further recorded in the ALS patients of the validation cohort.

Results

In the derivation cohort, the CD4⁺EOMES⁺T-cell subsets were significantly increased (p < 0.001). EOMES⁺ subset was positively correlated with increased serum NFL levels in patients with onset longer than 12 months. In the validation cohort, the elevated CD4⁺EOMES⁺T-cell proportions and their association with NFL levels were also identified. The longitudinal study revealed that ALS patients with higher EOMES expression were associated with higher progression rates (p = .010) and worse prognosis (p = .003).

Conclusions

We demonstrated that increased CD4⁺EOMES⁺T-cell subsets in ALS were associated with disease progression and poor prognosis. Identifying these associations may contribute to a better understanding of the immunopathological mechanism of ALS.

SUBMITTER: Chen S

PROVIDER: S-EPMC11017423 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Publications

Eomesodermin expression in CD4<sup>+</sup>T-cells associated with disease progression in amyotrophic lateral sclerosis.

Chen Sheng S Huan Xiao X Xu Chun-Zuan CZ Luo Su-Shan SS Zhao Chong-Bo CB Zhong Hua-Hua HH Zheng Xue-Ying XY Qiao Kai K Dong Yi Y Wang Ying Y Liu Chang-Yun CY Huang Hua-Pin HP Chen Yan Y Zou Zhang-Yu ZY

CNS neuroscience & therapeutics 20231018 4

<h4>Aim</h4>To clarify the role of Eomesodermin (EOMES) to serve as a disease-relevant biomarker and the intracellular molecules underlying the immunophenotype shifting of CD4<sup>+</sup>T subsets in amyotrophic lateral sclerosis (ALS).<h4>Methods</h4>The derivation and validation cohorts included a total of 148 ALS patients and 101 healthy controls (HCs). Clinical data and peripheral blood were collected. T-cell subsets and the EOMES expression were quantified using multicolor flow cytometry. S ...[more]

PMID: 37850654

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Dataset Information

Eomesodermin expression in CD4⁺T-cells associated with disease progression in amyotrophic lateral sclerosis.

Aim

Methods

Results

Conclusions

Publications

Eomesodermin expression in CD4<sup>+</sup>T-cells associated with disease progression in amyotrophic lateral sclerosis.

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OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Eomesodermin expression in CD4+T-cells associated with disease progression in amyotrophic lateral sclerosis.

Aim

Methods

Results

Conclusions

Publications

Eomesodermin expression in CD4<sup>+</sup>T-cells associated with disease progression in amyotrophic lateral sclerosis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Eomesodermin expression in CD4⁺T-cells associated with disease progression in amyotrophic lateral sclerosis.