Eomesodermin expression in CD4⁺T-cells associated with disease progression in amyotrophic lateral sclerosis.

ABSTRACT:

Aim

To clarify the role of Eomesodermin (EOMES) to serve as a disease-relevant biomarker and the intracellular molecules underlying the immunophenotype shifting of CD4⁺T subsets in amyotrophic lateral sclerosis (ALS).

Methods

The derivation and validation cohorts included a total of 148 ALS patients and 101 healthy controls (HCs). Clinical data and peripheral blood were collected. T-cell subsets and the EOMES expression were quantified using multicolor flow cytometry. Serum neurofilament light chain (NFL) was measured. In 1-year longitudinal follow-ups, the ALSFRS-R scores and primary endpoint events were further recorded in the ALS patients of the validation cohort.

Results

In the derivation cohort, the CD4⁺EOMES⁺T-cell subsets were s

SUBMITTER: Chen S 

PROVIDER: S-EPMC11017423 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature