The effect of dopamine replacement therapy on cortical structure in Parkinson's disease.

ABSTRACT:

Aims

To explore the cortical structural reorganization in Parkinson's disease (PD) patients under chronic dopamine replacement therapy (DRT) in cross-sectional and longitudinal data and determine whether these changes were associated with clinical alterations.

Methods

A total of 61 DRT-treated, 60 untreated PD patients, and 61 normal controls (NC) were retrospectively included. Structural MRI scans and neuropsychological tests were conducted. Cortical thickness and volume were extracted based on FreeSurfer and were analyzed using general linear model to find statistically significant differences among three groups. Correlation analyses were performed among significant cortical areas, medication treatment (duration and dosage), and neuropsychological tests. Longitudinal corti

SUBMITTER: Wu C 

PROVIDER: S-EPMC11017430 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature