Icaritin greatly attenuates β-amyloid-induced toxicity in vivo.

ABSTRACT:

Aims

The accumulation and deposition of β-amyloid (Aβ) has always been considered a major pathological feature of Alzheimer's disease (AD). The latest and mainstream amyloid cascade hypothesis indicates that all the main pathological changes in AD are attributed to the accumulation of soluble Aβ. However, the exploration of therapeutic drugs for Aβ toxicity has progressed slowly. This study aims to investigate the protective effects of Icaritin on the Aβ-induced Drosophila AD model and its possible mechanism.

Methods

To identify the effects of Icaritin on AD, we constructed an excellent Drosophila AD model named Aβ_arc (arctic mutant Aβ₄₂) Drosophila. Climbing ability, flight ability, and longevity were used to evaluate the effects of Icaritin on AD phen

SUBMITTER: Li L 

PROVIDER: S-EPMC11017459 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature