Different airborne particulates trigger distinct immune pathways leading to peanut allergy in a mouse model.

ABSTRACT:

Background

Environmental exposure to peanut through non-oral routes is a risk factor for peanut allergy. Early-life exposure to air pollutants, including particulate matter (PM), is associated with sensitization to foods through unknown mechanisms. We investigated whether PM promotes sensitization to environmental peanut and the development of peanut allergy in a mouse model.

Methods

C57BL/6J mice were co-exposed to peanut and either urban particulate matter (UPM) or diesel exhaust particles (DEP) via the airways and assessed for peanut sensitization and development of anaphylaxis following peanut challenge. Peanut-specific CD4⁺ T helper (Th) cell responses were characterized by flow cytometry and Th cytokine production. Mice lacking select innate immune signaling

SUBMITTER: Immormino RM 

PROVIDER: S-EPMC11017991 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature