Cohabiting with ulcerative colitis patients decreases differences of gut microbiome between healthy individuals and the patients.

ABSTRACT: Background: Ulcerative colitis (UC), which is characterized by chronic relapsing inflammation of the colon, results from a complex interaction of factors involving the host, environment, and microbiome. The present study aimed to investigate the gut microbial composition and metabolic variations in patients with UC and their spouses. Materials and Methods: Fecal samples were collected from 13 healthy spouses and couples with UC. 16S rRNA gene amplicon sequencing and metagenomics sequencing were used to analyze gut microbiota composition, pathways, gene expression, and enzyme activity, followed by the Kyoto Encyclopedia of Genes and Genomes. Results: We found that the microbiome diversity of couples with UC decreased, especially that of UC patients. Bacterial compositio

SUBMITTER: Li C 

PROVIDER: S-EPMC11017998 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature