Flow-Limited and Reverse-Triggered Ventilator Dyssynchrony Are Associated With Increased Tidal and Dynamic Transpulmonary Pressure.

ABSTRACT:

Objectives

Ventilator dyssynchrony may be associated with increased delivered tidal volumes (V t s) and dynamic transpulmonary pressure (ΔP L,dyn ), surrogate markers of lung stress and strain, despite low V t ventilation. However, it is unknown which types of ventilator dyssynchrony are most likely to increase these metrics or if specific ventilation or sedation strategies can mitigate this potential.

Design

A prospective cohort analysis to delineate the association between ten types of breaths and delivered V t , ΔP L,dyn , and transpulmonary mechanical energy.

Setting

Patients admitted to the medical ICU.

Patients

Over 580,000 breaths from 35 patients with acute respiratory distress syndrome (ARDS) or ARDS risk factors.

Interventions

None.

Measurem

SUBMITTER: Sottile PD 

PROVIDER: S-EPMC11018465 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature