Lower region-specific gray matter volume in females with atypical anorexia nervosa and anorexia nervosa.

ABSTRACT:

Objective

Few studies have focused on brain structure in atypical anorexia nervosa (atypical AN). This study investigates differences in gray matter volume (GMV) between females with anorexia nervosa (AN) and atypical AN, and healthy controls (HC).

Method

Structural magnetic resonance imaging data were acquired for 37 AN, 23 atypical AN, and 41 HC female participants. Freesurfer was used to extract GMV, cortical thickness, and surface area for six brain lobes and associated cortical regions of interest (ROI). Primary analyses employed linear mixed-effects models to compare group differences in lobar GMV, followed by secondary analyses on ROIs within significant lobes. We also explored relationships between cortical gray matter and both body mass index (BMI) and symptom sever

SUBMITTER: Lyall AE 

PROVIDER: S-EPMC11018478 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature