Minimum clinical utility standards for wearable seizure detectors: A simulation study.

ABSTRACT:

Objective

Epilepsy management employs self-reported seizure diaries, despite evidence of seizure underreporting. Wearable and implantable seizure detection devices are now becoming more widely available. There are no clear guidelines about what levels of accuracy are sufficient. This study aimed to simulate clinical use cases and identify the necessary level of accuracy for each.

Methods

Using a realistic seizure simulator (CHOCOLATES), a ground truth was produced, which was then sampled to generate signals from simulated seizure detectors of various capabilities. Five use cases were evaluated: (1) randomized clinical trials (RCTs), (2) medication adjustment in clinic, (3) injury prevention, (4) sudden unexpected death in epilepsy (SUDEP) prevention, and (5) treatment of sei

SUBMITTER: Goldenholz DM 

PROVIDER: S-EPMC11018505 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature