The efficacy and safety of vonoprazan in quadruple therapy for Helicobacter pylori eradication: a comparative study.

ABSTRACT:

Background

The efficacy and optimal dose of the new acid-suppressant vonoprazan (VPZ) for quadruple therapy remain uncertain. This study aimed to compare the efficacy and safety of 20 mg VPZ daily (VOD) and 20 mg VPZ twice daily (VTD) with a proton pump inhibitor (PPI) twice daily in quadruple therapy.

Methods

We retrospectively analyzed the data of 954 patients treated with quadruple therapy to eradicate Helicobacter pylori. Eradication rates and adverse events were compared between the VOD and VTD groups, and between the VOD and PPI groups. Multivariate analysis was conducted to identify the predictors of eradication failure.

Results

Eradication was successful in 875 (91.7%) of the 954 patients. The total, initial, and rescue eradication rates in the VOD grou

SUBMITTER: Zhuang X 

PROVIDER: S-EPMC11018536 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature