T cell-mediated tumor killing sensitivity gene signature-based prognostic score for acute myeloid leukemia.

ABSTRACT:

Background and objective

Acute myeloid leukemia (AML) is an aggressive, heterogenous hematopoetic malignancies with poor long-term prognosis. T-cell mediated tumor killing plays a key role in tumor immunity. Here, we explored the prognostic performance and functional significance of a T-cell mediated tumor killing sensitivity gene (GSTTK)-based prognostic score (TTKPI).

Methods

Publicly available transcriptomic data for AML were obtained from TCGA and NCBI-GEO. GSTTK were identified from the TISIDB database. Signature GSTTK for AML were identified by differential expression analysis, COX proportional hazards and LASSO regression analysis and a comprehensive TTKPI score was constructed. Prognostic performance of the TTKPI was examined using Kaplan-Meier survival analysis, Rec

SUBMITTER: Pan Y 

PROVIDER: S-EPMC11018597 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature