Prognostic modeling in early rheumatoid arthritis: reconsidering the predictive role of disease activity scores.

ABSTRACT:

Objective

In this prospective cohort study, we provide several prognostic models to predict functional status as measured by the modified Health Assessment Questionnaire (mHAQ). The early adoption of the treat-to-target strategy in this cohort offered a unique opportunity to identify predictive factors using longitudinal data across 20 years.

Methods

A cohort of 397 patients with early RA was used to develop statistical models to predict mHAQ score measured at baseline, 12 months, and 18 months post diagnosis, as well as serially measured mHAQ. Demographic data, clinical measures, autoantibodies, medication use, comorbid conditions, and baseline mHAQ were considered as predictors.

Results

The discriminative performance of models was comparable to previous work, with a

SUBMITTER: Bird A 

PROVIDER: S-EPMC11018671 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature