OPN silencing reduces hypoxic pulmonary hypertension via PI3K-AKT-induced protective autophagy.

ABSTRACT: Hypoxic pulmonary hypertension (HPH) is a pulmonary vascular disease primarily characterized by progressive pulmonary vascular remodeling in a hypoxic environment, posing a significant clinical challenge. Leveraging data from the Gene Expression Omnibus (GEO) and human autophagy-specific databases, osteopontin (OPN) emerged as a differentially expressed gene, upregulated in cardiovascular diseases such as pulmonary arterial hypertension (PAH). Despite this association, the precise mechanism by which OPN regulates autophagy in HPH remains unclear, prompting the focus of this study. Through biosignature analysis, we observed significant alterations in the PI3K-AKT signaling pathway in PAH-associated autophagy. Subsequently, we utilized an animal model of OPN^fl/fl-TAGLN-Cre mice an

SUBMITTER: Zhou R 

PROVIDER: S-EPMC11018812 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature