Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis.

ABSTRACT:

Background

Androgenetic alopecia (AGA) is the most common type of androgen-associated hair loss. Previous studies have indicated an association between the gut microbiota and AGA. To delve deeper, we executed a two-sample Mendelian randomization (MR) analysis to investigate the potential causal relationship between the gut microbiota and AGA.

Methods

A two-sample MR investigation was utilized to delve into the intricate interplay between gut microbiota and AGA. Information regarding 211 gut microbial taxa was sourced from the MiBioGen consortium. The summary statistics of the genome-wide association studies (GWAS) for AGA were obtained from the FinnGen biobank, which included 195 cases and 201,019 controls. Various analytical approaches, including Inverse Variance Weighting

SUBMITTER: Fu H 

PROVIDER: S-EPMC11018880 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature